Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor

The neuromodulator dopamine signals through the dopamine D2 receptor (D(2)R) to modulate central nervous system functions through diverse signal transduction pathways. D(2)R is a prominent target for drug treatments in disorders where dopamine function is aberrant, such as schizophrenia. D(2)R signa...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Peterson, Sean M., Pack, Thomas F., Wilkins, Angela D., Urs, Nikhil M., Urban, Daniel J., Bass, Caroline E., Lichtarge, Olivier, Caron, Marc G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2015
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460444/
https://ncbi.nlm.nih.gov/pubmed/25964346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502742112
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