Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions

The dopamine D2 receptor (D2R), like many G-protein-coupled receptors, signals through G-protein- and β-arrestin-dependent pathways. Preferential activation of one of these pathways is termed functional selectivity or biased signaling and is a promising therapeutic strategy. Though biased signaling...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Neuropsychopharmacology
Egile Nagusiak: Rose, Samuel J, Pack, Thomas F, Peterson, Sean M, Payne, Kaitlin, Borrelli, Emiliana, Caron, Marc G
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2018
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854808/
https://ncbi.nlm.nih.gov/pubmed/29068002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.254
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