Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties

The current dopamine (DA) hypothesis of schizophrenia postulates striatal hyperdopaminergia and cortical hypodopaminergia. Although partial agonists at DA D2 receptors (D2Rs), like aripiprazole, were developed to simultaneously target both phenomena, they do not effectively improve cortical dysfunct...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Urs, Nikhil M., Gee, Steven M., Pack, Thomas F., McCorvy, John D., Evron, Tama, Snyder, Joshua C., Yang, Xiaobao, Rodriguiz, Ramona M., Borrelli, Emiliana, Wetsel, William C., Jin, Jian, Roth, Bryan L., O’Donnell, Patricio, Caron, Marc G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167191/
https://ncbi.nlm.nih.gov/pubmed/27911814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614347113
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