The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface

We recently reported the discovery of UNC1215, a potent and selective chemical probe for the L3MBTL3 methyllysine reader domain. In this article, we describe the development of structure-activity relationships (SAR) of a second series of potent L3MBTL3 antagonists which evolved from the structure of...

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Detalhes bibliográficos
Main Authors: Camerino, Michelle A., Zhong, Nan, Dong, Aiping, Dickson, Bradley M., James, Lindsey I., Baughman, Brandi M., Norris, Jacqueline L., Kireev, Dmitri B., Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897169/
https://ncbi.nlm.nih.gov/pubmed/24466405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD00197K
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