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The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface
We recently reported the discovery of UNC1215, a potent and selective chemical probe for the L3MBTL3 methyllysine reader domain. In this article, we describe the development of structure-activity relationships (SAR) of a second series of potent L3MBTL3 antagonists which evolved from the structure of...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3897169/ https://ncbi.nlm.nih.gov/pubmed/24466405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD00197K |
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