The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface

We recently reported the discovery of UNC1215, a potent and selective chemical probe for the L3MBTL3 methyllysine reader domain. In this article, we describe the development of structure-activity relationships (SAR) of a second series of potent L3MBTL3 antagonists which evolved from the structure of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Camerino, Michelle A., Zhong, Nan, Dong, Aiping, Dickson, Bradley M., James, Lindsey I., Baughman, Brandi M., Norris, Jacqueline L., Kireev, Dmitri B., Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897169/
https://ncbi.nlm.nih.gov/pubmed/24466405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD00197K
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak