Towards functional selectivity for α6β3γ2 GABA(A) receptors: a series of novel pyrazoloquinolinones

BACKGROUND AND PURPOSE: The GABA(A) receptors are ligand‐gated ion channels, which play an important role in neurotransmission. Their variety of binding sites serves as an appealing target for many clinically relevant drugs. Here, we explored the functional selectivity of modulatory effects at speci...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Treven, Marco, Siebert, David C B, Holzinger, Raphael, Bampali, Konstantina, Fabjan, Jure, Varagic, Zdravko, Wimmer, Laurin, Steudle, Friederike, Scholze, Petra, Schnürch, Michael, Mihovilovic, Marko D, Ernst, Margot
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773961/
https://ncbi.nlm.nih.gov/pubmed/29127702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14087
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