Towards functional selectivity for α6β3γ2 GABA(A) receptors: a series of novel pyrazoloquinolinones

BACKGROUND AND PURPOSE: The GABA(A) receptors are ligand‐gated ion channels, which play an important role in neurotransmission. Their variety of binding sites serves as an appealing target for many clinically relevant drugs. Here, we explored the functional selectivity of modulatory effects at speci...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Treven, Marco, Siebert, David C B, Holzinger, Raphael, Bampali, Konstantina, Fabjan, Jure, Varagic, Zdravko, Wimmer, Laurin, Steudle, Friederike, Scholze, Petra, Schnürch, Michael, Mihovilovic, Marko D, Ernst, Margot
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773961/
https://ncbi.nlm.nih.gov/pubmed/29127702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14087
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