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Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor
Benzodiazepines (BZDs) and barbiturates exert their CNS actions by binding to GABA-A receptors (GABARs). The structural mechanisms by which these drugs allosterically modulate GABAR function, to either enhance or inhibit GABA-gated current, are poorly understood. Here, we used the substituted cystei...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3026633/ https://ncbi.nlm.nih.gov/pubmed/21093460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.11.009 |
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