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Structural requirements for eszopiclone and zolpidem binding to the GABA(A) receptor are different

The sleep-aids, zolpidem and eszopiclone, exert their effects by binding to and modulating GABA(A) receptors (GABA(A)Rs), but little is known about the structural requirements for their actions. We made 24 cysteine mutations in the benzodiazepine (BZD) binding site of α(1)β(2)γ(2) GABA(A)Rs, and mea...

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書誌詳細
主要な著者: Hanson, Susan M., Morlock, Elaine V., Satyshur, Kenneth A., Czajkowski, Cynthia
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645942/
https://ncbi.nlm.nih.gov/pubmed/18973287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800889m
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