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Structural requirements for eszopiclone and zolpidem binding to the GABA(A) receptor are different
The sleep-aids, zolpidem and eszopiclone, exert their effects by binding to and modulating GABA(A) receptors (GABA(A)Rs), but little is known about the structural requirements for their actions. We made 24 cysteine mutations in the benzodiazepine (BZD) binding site of α(1)β(2)γ(2) GABA(A)Rs, and mea...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2645942/ https://ncbi.nlm.nih.gov/pubmed/18973287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800889m |
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