Non-Invasive Bioluminescence Imaging of β-Cell Function in Obese-Hyperglycemic [ob/ob] Mice

BACKGROUND: Type 2 diabetes results from failure of the β-cells to compensate for increased insulin demand due to abnormal levels of metabolic factors. The ob/ob(lep-/-) mouse has been extensively studied as an animal model of type 2 diabetes. Previous studies have shown a correlation between β-cell...

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Detalhes bibliográficos
Main Authors: Patel, Manishkumar, Gleason, Alexa, O'Malley, Stacey, Connolly, Brett, Suresch, Donna, Virostko, John, Phillips, Neil, Lin, Shu-An, Chen, Tsing-Bau, Klimas, Michael, Hargreaves, Richard J., Sur, Cyrille, Williams, David L., Powers, Alvin C., Bednar, Bohumil
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157804/
https://ncbi.nlm.nih.gov/pubmed/25198535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106693
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