Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators

Dual orexin receptor antagonists (DORAs) are a potential treatment for insomnia that function by blocking both the orexin 1 and orexin 2 receptors. The objective of the current study was to further confirm the impact of therapeutic mechanisms targeting insomnia on locomotor coordination and ethanol...

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Autors principals: Ramirez, Andres D., Gotter, Anthony L., Fox, Steven V., Tannenbaum, Pamela L., Yao, Lihang, Tye, Spencer J., McDonald, Terrence, Brunner, Joseph, Garson, Susan L., Reiss, Duane R., Kuduk, Scott D., Coleman, Paul J., Uslaner, Jason M., Hodgson, Robert, Browne, Susan E., Renger, John J., Winrow, Christopher J.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2013
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871832/
https://ncbi.nlm.nih.gov/pubmed/24399926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2013.00254
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