Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators

Dual orexin receptor antagonists (DORAs) are a potential treatment for insomnia that function by blocking both the orexin 1 and orexin 2 receptors. The objective of the current study was to further confirm the impact of therapeutic mechanisms targeting insomnia on locomotor coordination and ethanol...

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Main Authors: Ramirez, Andres D., Gotter, Anthony L., Fox, Steven V., Tannenbaum, Pamela L., Yao, Lihang, Tye, Spencer J., McDonald, Terrence, Brunner, Joseph, Garson, Susan L., Reiss, Duane R., Kuduk, Scott D., Coleman, Paul J., Uslaner, Jason M., Hodgson, Robert, Browne, Susan E., Renger, John J., Winrow, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2013
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871832/
https://ncbi.nlm.nih.gov/pubmed/24399926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2013.00254
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