Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man

Orexin neuropeptides regulate sleep/wake through orexin receptors (OX(1)R, OX(2)R); OX(2)R is the predominant mediator of arousal promotion. The potential for single OX(2)R antagonism to effectively promote sleep has yet to be demonstrated in humans. MK-1064 is an OX(2)R-single antagonist. Preclinic...

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Vydáno v:Sci Rep
Hlavní autoři: Gotter, Anthony L., Forman, Mark S., Harrell, Charles M., Stevens, Joanne, Svetnik, Vladimir, Yee, Ka Lai, Li, Xiaodong, Roecker, Anthony J., Fox, Steven V., Tannenbaum, Pamela L., Garson, Susan L., Lepeleire, Inge De, Calder, Nicole, Rosen, Laura, Struyk, Arie, Coleman, Paul J., Herring, W. Joseph, Renger, John J., Winrow, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891657/
https://ncbi.nlm.nih.gov/pubmed/27256922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27147
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