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Discovery and development of orexin receptor antagonists as therapeutics for insomnia

Insomnia persistently affects the quality and quantity of sleep. Currently approved treatments for insomnia primarily target γ-aminobutyric acid-A (GABA-A) receptor signalling and include benzodiazepines and GABA-A receptor modulators. These drugs are used to address this sleep disorder, but have th...

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Bibliografski detalji
Glavni autori: Winrow, CJ, Renger, JJ
Format: Artigo
Jezik:Inglês
Izdano: The British Pharmacological Society 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904252/
https://ncbi.nlm.nih.gov/pubmed/23731216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12261
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