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Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands
Orexin receptor antagonism represents a novel approach for the treatment of insomnia that directly targets sleep/wake regulation. Several such compounds have entered into clinical development, including the dual orexin receptor antagonists, suvorexant and almorexant. In this study, we have used equi...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The British Pharmacological Society
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904256/ https://ncbi.nlm.nih.gov/pubmed/23692283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12245 |
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