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Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands

Orexin receptor antagonism represents a novel approach for the treatment of insomnia that directly targets sleep/wake regulation. Several such compounds have entered into clinical development, including the dual orexin receptor antagonists, suvorexant and almorexant. In this study, we have used equi...

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Bibliografski detalji
Glavni autori: Mould, R, Brown, J, Marshall, FH, Langmead, CJ
Format: Artigo
Jezik:Inglês
Izdano: The British Pharmacological Society 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904256/
https://ncbi.nlm.nih.gov/pubmed/23692283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12245
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