MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

HCV NS3/4a protease inhibitors are proven therapeutic agents against chronic hepatitis C virus infection, with boceprevir and telaprevir having recently received regulatory approval as add-on therapy to pegylated interferon/ribavirin for patients harboring genotype 1 infections. Overcoming antiviral...

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Detalhes bibliográficos
Main Authors: Summa, Vincenzo, Ludmerer, Steven W., McCauley, John A., Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J., DiMuzio, Jillian M., Ferrara, Marco, Di Filippo, Marcello, Gates, Adam T., Graham, Donald J., Harper, Steven, Hazuda, Daria J., McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T., Soriano, Aileen, Stahlhut, Mark W., Vacca, Joseph P., Olsen, David B., Liverton, Nigel J., Carroll, Steven S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421554/
https://ncbi.nlm.nih.gov/pubmed/22615282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00324-12
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