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Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172
Recent advances in direct-acting antivirals against Hepatitis C Virus (HCV) have led to the development of potent inhibitors, including MK-5172, that target the viral NS3/4A protease with relatively low susceptibility to resistance. MK-5172 has a P2–P4 macrocycle and a unique binding mode among curr...
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| Veröffentlicht in: | ACS Chem Biol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5099976/ https://ncbi.nlm.nih.gov/pubmed/26682473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00647 |
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