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Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172

Recent advances in direct-acting antivirals against Hepatitis C Virus (HCV) have led to the development of potent inhibitors, including MK-5172, that target the viral NS3/4A protease with relatively low susceptibility to resistance. MK-5172 has a P2–P4 macrocycle and a unique binding mode among curr...

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Dades bibliogràfiques
Publicat a:ACS Chem Biol
Autors principals: Soumana, Djadé I., Yilmaz, Nese Kurt, Prachanronarong, Kristina L., Aydin, Cihan, Ali, Akbar, Schiffer, Celia A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099976/
https://ncbi.nlm.nih.gov/pubmed/26682473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00647
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