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Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease
[Image: see text] Asunaprevir (ASV), an isoquinoline-based competitive inhibitor targeting the hepatitis C virus (HCV) NS3/4A protease, is very potent in vivo. However, the potency is significantly compromised by the drug resistance mutations R155K and D168A. In this study three crystal structures o...
Guardat en:
| Publicat a: | ACS Chem Biol |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2014
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4245159/ https://ncbi.nlm.nih.gov/pubmed/25243902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb5006118 |
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