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Molecular and structural mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir
Hepatitis C virus (HCV), causative agent of chronic viral hepatitis, infects 71 million people worldwide and is divided into seven genotypes and multiple subtypes with sequence identities between 68 to 82%. While older generation direct-acting antivirals (DAAs) had varying effectiveness against diff...
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| Опубликовано в: : | ACS Chem Biol |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7747061/ https://ncbi.nlm.nih.gov/pubmed/31868341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00675 |
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