Molecular Mechanism of Resistance in a Clinically Significant Double Mutant Variant of HCV NS3/4A Protease

Despite significant progress in hepatitis C virus protease inhibitor (PI) drug design, resistance remains a problem causing treatment failure. Double substitution variants, notably Y56H/D168A have emerged in patients who fail therapy with a PI-containing regimen. The resistance conferred by Asp168 s...

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Publicado no:Structure
Main Authors: Matthew, Ashley N., Leidner, Florian, Newton, Alicia, Petropoulos, Christos J., Huang, Wei, Ali, Akbar, Kurt-Yilmaz, Nese, Schiffer, Celia A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260965/
https://ncbi.nlm.nih.gov/pubmed/30146168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.07.004
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