Structural Adaptation of Darunavir Analogs Against Primary Mutations in HIV-1 Protease

HIV-1 protease is one of the prime targets of agents used in antiretroviral therapy against HIV. However, under selective pressure of protease inhibitors, primary mutations at the active site weaken inhibitor binding to confer resistance. Darunavir (DRV) is the most potent HIV-1 protease inhibitor i...

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Bibliographic Details
Published in:ACS Infect Dis
Main Authors: Lockbaum, Gordon J., Leidner, Florian, Rusere, Linah N., Henes, Mina, Kosovrasti, Klajdi, Nachum, Gily S., Nalivaika, Ellen A., Bolon, Daniel N.A., Ali, Akbar, Yilmaz, Nese Kurt, Schiffer, Celia A.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941150/
https://ncbi.nlm.nih.gov/pubmed/30543749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00336
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