Structural Adaptation of Darunavir Analogs Against Primary Mutations in HIV-1 Protease

HIV-1 protease is one of the prime targets of agents used in antiretroviral therapy against HIV. However, under selective pressure of protease inhibitors, primary mutations at the active site weaken inhibitor binding to confer resistance. Darunavir (DRV) is the most potent HIV-1 protease inhibitor i...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Lockbaum, Gordon J., Leidner, Florian, Rusere, Linah N., Henes, Mina, Kosovrasti, Klajdi, Nachum, Gily S., Nalivaika, Ellen A., Bolon, Daniel N.A., Ali, Akbar, Yilmaz, Nese Kurt, Schiffer, Celia A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941150/
https://ncbi.nlm.nih.gov/pubmed/30543749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00336
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