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Structural Adaptation of Darunavir Analogs Against Primary Mutations in HIV-1 Protease
HIV-1 protease is one of the prime targets of agents used in antiretroviral therapy against HIV. However, under selective pressure of protease inhibitors, primary mutations at the active site weaken inhibitor binding to confer resistance. Darunavir (DRV) is the most potent HIV-1 protease inhibitor i...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ACS Infect Dis |
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| Κύριοι συγγραφείς: | , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6941150/ https://ncbi.nlm.nih.gov/pubmed/30543749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00336 |
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