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pM to μM - Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance
Drug resistance continues to be a growing, global problem. The efficacy of small molecule inhibitors is threatened by pools of genetic diversity in all systems, including antibacterials, antifungals, cancer therapeutics, and antivirals. Resistant variants often include combinations of active site mu...
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| 發表在: | ACS Chem Biol |
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| Main Authors: | , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6941144/ https://ncbi.nlm.nih.gov/pubmed/31361460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00370 |
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