pM to μM - Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance

Drug resistance continues to be a growing, global problem. The efficacy of small molecule inhibitors is threatened by pools of genetic diversity in all systems, including antibacterials, antifungals, cancer therapeutics, and antivirals. Resistant variants often include combinations of active site mu...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Henes, Mina, Lockbaum, Gordon J., Kosovrasti, Klajdi, Leidner, Florian, Nachum, Gily S., Nalivaika, Ellen A., Lee, Sook-Kyung, Spielvogel, Ean, Zhou, Shuntai, Swanstrom, Ronald, Bolon, Daniel N.A., Yilmaz, Nese Kurt, Schiffer, Celia A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941144/
https://ncbi.nlm.nih.gov/pubmed/31361460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00370
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