pM to μM - Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance

Drug resistance continues to be a growing, global problem. The efficacy of small molecule inhibitors is threatened by pools of genetic diversity in all systems, including antibacterials, antifungals, cancer therapeutics, and antivirals. Resistant variants often include combinations of active site mu...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:ACS Chem Biol
Hlavní autoři: Henes, Mina, Lockbaum, Gordon J., Kosovrasti, Klajdi, Leidner, Florian, Nachum, Gily S., Nalivaika, Ellen A., Lee, Sook-Kyung, Spielvogel, Ean, Zhou, Shuntai, Swanstrom, Ronald, Bolon, Daniel N.A., Yilmaz, Nese Kurt, Schiffer, Celia A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941144/
https://ncbi.nlm.nih.gov/pubmed/31361460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00370
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky