pM to μM - Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance

Drug resistance continues to be a growing, global problem. The efficacy of small molecule inhibitors is threatened by pools of genetic diversity in all systems, including antibacterials, antifungals, cancer therapeutics, and antivirals. Resistant variants often include combinations of active site mu...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Henes, Mina, Lockbaum, Gordon J., Kosovrasti, Klajdi, Leidner, Florian, Nachum, Gily S., Nalivaika, Ellen A., Lee, Sook-Kyung, Spielvogel, Ean, Zhou, Shuntai, Swanstrom, Ronald, Bolon, Daniel N.A., Yilmaz, Nese Kurt, Schiffer, Celia A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941144/
https://ncbi.nlm.nih.gov/pubmed/31361460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00370
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