Structural Adaptation of Darunavir Analogs Against Primary Mutations in HIV-1 Protease

HIV-1 protease is one of the prime targets of agents used in antiretroviral therapy against HIV. However, under selective pressure of protease inhibitors, primary mutations at the active site weaken inhibitor binding to confer resistance. Darunavir (DRV) is the most potent HIV-1 protease inhibitor i...

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Bibliografiset tiedot
Julkaisussa:ACS Infect Dis
Päätekijät: Lockbaum, Gordon J., Leidner, Florian, Rusere, Linah N., Henes, Mina, Kosovrasti, Klajdi, Nachum, Gily S., Nalivaika, Ellen A., Bolon, Daniel N.A., Ali, Akbar, Yilmaz, Nese Kurt, Schiffer, Celia A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941150/
https://ncbi.nlm.nih.gov/pubmed/30543749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00336
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