The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities

Por Aydin, Cihan, Mukherjee, Sourav, Hanson, Alicia M, Frick, David N, Schiffer, Celia A
Publicado em 2013

Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172

Por Soumana, Djadé I., Yilmaz, Nese Kurt, Prachanronarong, Kristina L., Aydin, Cihan, Ali, Akbar, Schiffer, Celia A.
Publicado no ACS Chem Biol (2016)

Evaluating the Role of Macrocycles in the Susceptibility of Hepatitis C Virus NS3/4A Protease Inhibitors to Drug Resistance

Por Ali, Akbar, Aydin, Cihan, Gildemeister, Reinhold, Romano, Keith P., Cao, Hong, Özen, Ayşegül, Soumana, Djade, Newton, Alicia, Petropoulos, Christos J., Huang, Wei, Schiffer, Celia A.
Publicado em 2013

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

Por Romano, Keith P., Ali, Akbar, Aydin, Cihan, Soumana, Djade, Özen, Ayşegül, Deveau, Laura M., Silver, Casey, Cao, Hong, Newton, Alicia, Petropoulos, Christos J., Huang, Wei, Schiffer, Celia A.
Publicado em 2012

Simultaneously Targeting the NS3 Protease And Helicase Activities For More Effective Hepatitis C Virus Therapy

Por Ndjomou, Jean, Corby, M. Josie, Sweeney, Noreena L., Hanson, Alicia M., Aydin, Cihan, Ali, Akbar, Schiffer, Celia A., Li, Kelin, Frankowski, Kevin J., Schoenen, Frank J., Frick, David N.
Publicado no ACS Chem Biol (2015)