Simultaneously Targeting the NS3 Protease And Helicase Activities For More Effective Hepatitis C Virus Therapy

This study examines the specificity and mechanism of action of a recently reported hepatitis C virus (HCV) non-structural protein 3 (NS3) helicase-protease inhibitor (HPI), and the interaction of HPI with the NS3 protease inhibitors telaprevir, boceprevir, danoprevir, and grazoprevir. HPI most effec...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:ACS Chem Biol
Egile Nagusiak: Ndjomou, Jean, Corby, M. Josie, Sweeney, Noreena L., Hanson, Alicia M., Aydin, Cihan, Ali, Akbar, Schiffer, Celia A., Li, Kelin, Frankowski, Kevin J., Schoenen, Frank J., Frick, David N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546510/
https://ncbi.nlm.nih.gov/pubmed/25961497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00101
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