Primuline Derivatives That Mimic RNA to Stimulate Hepatitis C Virus NS3 Helicase-catalyzed ATP Hydrolysis

ATP hydrolysis fuels the ability of helicases and related proteins to translocate on nucleic acids and separate base pairs. As a consequence, nucleic acid binding stimulates the rate at which a helicase catalyzes ATP hydrolysis. In this study, we searched a library of small molecule helicase inhibit...

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Detalles Bibliográficos
Autores principales: Sweeney, Noreena L., Shadrick, William R., Mukherjee, Sourav, Li, Kelin, Frankowski, Kevin J., Schoenen, Frank J., Frick, David N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707695/
https://ncbi.nlm.nih.gov/pubmed/23703611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463166
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