Fluorescent Primuline Derivatives Inhibit Hepatitis C Virus NS3-Catalyzed RNA Unwinding, Peptide Hydrolysis and Viral Replicase Formation

The hepatitis C virus (HCV) multifunctional nonstructural protein 3 (NS3) is a protease that cleaves viral and host proteins and a helicase that separates DNA and RNA structures in reactions fueled by ATP hydrolysis. Li et al. (J. Med. Chem. 2012, 55:3319-3330) recently synthesized a series of new N...

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Main Authors: Ndjomou, Jean, Kolli, Rajesh, Mukherjee, Sourav, Shadrick, William R., Hanson, Alicia M., Sweeney, Noreena L., Bartczak, Diana, Li, Kelin, Frankowski, Kevin J., Schoenen, Frank J., Frick, David N.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571690/
https://ncbi.nlm.nih.gov/pubmed/22940425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2012.08.006
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