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Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M(1) Positive Allosteric Modulators

This Letter describes the chemical optimization of a new series of muscarinic acetylcholine receptor subtype 1 (M(1)) positive allosteric modulators (PAMs) based on novel tricyclic triazolo- and imidazopyridine lactam cores, devoid of M(1) agonism, e.g., no M(1) ago-PAM activity, in high expressing...

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發表在:ACS Chem Neurosci
Main Authors: Engers, Julie L., Bender, Aaron M., Kalbfleisch, Jacob J., Cho, Hyekyung P., Lingenfelter, Kaelyn S., Luscombe, Vincent B., Han, Changho, Melancon, Bruce J., Blobaum, Anna L., Dickerson, Jonathan W., Rook, Jerri M., Niswender, Colleen M., Emmitte, Kyle A., Conn, P. Jeffrey, Lindsley, Craig W.
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456254/
https://ncbi.nlm.nih.gov/pubmed/30086237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00311
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