Interferon-β gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice

由 Qin, Xiao-Qiang, Tao, Nianjun, Dergay, Amie, Moy, Pamela, Fawell, Stephen, Davis, Alan, Wilson, James M., Barsoum, James
出版 1998

Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers

由 Bihani, Teeru, Ezell, Scott A., Ladd, Brendon, Grosskurth, Shaun E., Mazzola, Anne Marie, Pietras, Mark, Reimer, Corinne, Zinda, Michael, Fawell, Stephen, D'Cruz, Celina M.
發表在 Oncotarget (2014)

BRD4 facilitates replication stress-induced DNA damage response

由 Zhang, Jingwen, Dulak, Austin M., Hattersley, Maureen M., Willis, Brandon S., Nikkilä, Jenni, Wang, Anderson, Lau, Alan, Reimer, Corinne, Zinda, Michael, Fawell, Stephen E., Mills, Gordon B., Chen, Huawei
發表在 Oncogene (2018)

Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas

由 Boiko, Scott, Proia, Theresa, San Martin, Maryann, Gregory, Gareth P., Wu, Michelle Min, Aryal, Neeraj, Hattersley, Maureen, Shao, Wenlin, Saeh, Jamal C., Fawell, Stephen E., Johnstone, Ricky W., Drew, Lisa, Cidado, Justin
發表在 Blood (2021)

BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors

由 Rhyasen, Garrett W., Yao, Yi, Zhang, Jingwen, Dulak, Austin, Castriotta, Lillian, Jacques, Kelly, Zhao, Wei, Gharahdaghi, Farzin, Hattersley, Maureen M., Lyne, Paul D., Clark, Edwin, Zinda, Michael, Fawell, Stephen E., Mills, Gordon B., Chen, Huawei
發表在 PLoS One (2018)

Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum

由 Greenawalt, Danielle M., Liang, Winnie S., Saif, Sakina, Johnson, Justin, Todorov, Petar, Dulak, Austin, Enriquez, Daniel, Halperin, Rebecca, Ahmed, Ambar, Saveliev, Vladislav, Carpten, John, Craig, David, Barrett, J. Carl, Dougherty, Brian, Zinda, Michael, Fawell, Stephen, Dry, Jonathan R., Byth, Kate
發表在 Oncotarget (2017)

Systemic IFN-β gene therapy results in long-term survival in mice with established colorectal liver metastases

由 Tada, Hiroomi, Maron, David J., Choi, Eugene A., Barsoum, James, Lei, Hanqin, Xie, Qing, Liu, Wenbiao, Ellis, Lee, Moscioni, A. David, Tazelaar, John, Fawell, Stephen, Qin, Xiao, Propert, Kathleen J., Davis, Alan, Fraker, Douglas L., Wilson, James M., Spitz, Francis R.
出版 2001

Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors

由 Zhang, Weisheng, Haines, Brian B, Efferson, Clay, Zhu, Joe, Ware, Chris, Kunii, Kaiko, Tammam, Jennifer, Angagaw, Minilik, Hinton, Marlene C, Keilhack, Heike, Paweletz, Cloud P, Zhang, Theresa, Winter, Chris, Sathyanarayanan, Sriram, Cheng, Jonathan, Zawel, Leigh, Fawell, Stephen, Gilliland, Gary, Majumder, Pradip K
出版 2012

Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations

由 Ladd, Brendon, Mazzola, Anne Marie, Bihani, Teeru, Lai, Zhongwu, Bradford, James, Collins, Michael, Barry, Evan, Goeppert, Anne U., Weir, Hazel M., Hearne, Kelly, Renshaw, Jonathan G., Mohseni, Morvarid, Hurt, Elaine, Jalla, Sanjoo, Bao, Haifeng, Hollingsworth, Robert, Reimer, Corinne, Zinda, Michael, Fawell, Stephen, D'Cruz, Celina M.
發表在 Oncotarget (2016)

BRD4 inhibition is synthetic lethal with PARP inhibitors through the induction of homologous recombination deficiency

由 Sun, Chaoyang, Yin, Jun, Fang, Yong, Chen, Jian, Jeong, Kang Jin, Chen, Xiaohua, Vellano, Christopher P., Ju, Zhenlin, Zhao, Wei, Zhang, Dong, Lu, Yiling, Meric-Bernstam, Funda, Yap, Timothy A., Hattersley, Maureen, O’Connor, Mark, Chen, Huawei, Fawell, Stephen, Lin, Shiaw-Yih, Peng, Guang, Mills, Gordon B.
發表在 Cancer Cell (2018)

Small molecule AZD4635 inhibitor of A(2A)R signaling rescues immune cell function including CD103(+) dendritic cells enhancing anti-tumor immunity

由 Borodovsky, Alexandra, Barbon, Christine M, Wang, Yanjun, Ye, Minwei, Prickett, Laura, Chandra, Dinesh, Shaw, Joseph, Deng, Nanhua, Sachsenmeier, Kris, Clarke, James D, Linghu, Bolan, Brown, Giles A, Brown, James, Congreve, Miles, Cheng, Robert KY, Dore, Andrew S, Hurrell, Edward, Shao, Wenlin, Woessner, Richard, Reimer, Corinne, Drew, Lisa, Fawell, Stephen, Schuller, Alwin G, Mele, Deanna A
發表在 J Immunother Cancer (2020)

Discovery of biomarkers predictive of GSI response in triple negative breast cancer and adenoid cystic carcinoma

由 Stoeck, Alexander, Lejnine, Serguei, Truong, Andrew, Pan, Li, Wang, Hongfang, Zang, Chongzhi, Yuan, Jing, Ware, Chris, MacLean, John, Garrett-Engele, Philip W, Kluk, Michael, Laskey, Jason, Haines, Brian B., Moskaluk, Christopher, Zawel, Leigh, Fawell, Stephen, Gilliland, Gary, Zhang, Theresa, Kremer, Brandon, Knoechel, Birgit, Bernstein, Bradley E, Pear, Warren S., Liu, X. Shirley, Aster, Jon C, Sathyanarayanan, Sriram
出版 2014

Drug mechanism‐of‐action discovery through the integration of pharmacological and CRISPR screens

由 Gonçalves, Emanuel, Segura‐Cabrera, Aldo, Pacini, Clare, Picco, Gabriele, Behan, Fiona M, Jaaks, Patricia, Coker, Elizabeth A, van der Meer, Donny, Barthorpe, Andrew, Lightfoot, Howard, Mironenko, Tatiana, Beck, Alexandra, Richardson, Laura, Yang, Wanjuan, Lleshi, Ermira, Hall, James, Tolley, Charlotte, Hall, Caitlin, Mali, Iman, Thomas, Frances, Morris, James, Leach, Andrew R, Lynch, James T, Sidders, Ben, Crafter, Claire, Iorio, Francesco, Fawell, Stephen, Garnett, Mathew J
發表在 Mol Syst Biol (2020)

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

由 Ettenberg, Seth A., Charlat, Olga, Daley, Michael P., Liu, Shanming, Vincent, Karen J., Stuart, Darrin D., Schuller, Alwin G., Yuan, Jing, Ospina, Beatriz, Green, John, Yu, Qunyan, Walsh, Renee, Li, Sharon, Schmitz, Rita, Heine, Holger, Bilic, Sanela, Ostrom, Lance, Mosher, Rebecca, Hartlepp, K. Felix, Zhu, Zhenping, Fawell, Stephen, Yao, Yung-Mae, Stover, David, Finan, Peter M., Porter, Jeffery A., Sellers, William R., Klagge, Ingo M., Cong, Feng
出版 2010

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

由 Menden, Michael P., Wang, Dennis, Mason, Mike J., Szalai, Bence, Bulusu, Krishna C., Guan, Yuanfang, Yu, Thomas, Kang, Jaewoo, Jeon, Minji, Wolfinger, Russ, Nguyen, Tin, Zaslavskiy, Mikhail, Jang, In Sock, Ghazoui, Zara, Ahsen, Mehmet Eren, Vogel, Robert, Neto, Elias Chaibub, Norman, Thea, Tang, Eric K. Y., Garnett, Mathew J., Veroli, Giovanni Y. Di, Fawell, Stephen, Stolovitzky, Gustavo, Guinney, Justin, Dry, Jonathan R., Saez-Rodriguez, Julio
發表在 Nat Commun (2019)

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

由 Fok, Jacqueline H. L., Ramos-Montoya, Antonio, Vazquez-Chantada, Mercedes, Wijnhoven, Paul W. G., Follia, Valeria, James, Neil, Farrington, Paul M., Karmokar, Ankur, Willis, Sophie E., Cairns, Jonathan, Nikkilä, Jenni, Beattie, David, Lamont, Gillian M., Finlay, M. Raymond V., Wilson, Joanne, Smith, Aaron, O’Connor, Lenka Oplustil, Ling, Stephanie, Fawell, Stephen E., O’Connor, Mark J., Hollingsworth, Simon J., Dean, Emma, Goldberg, Frederick W., Davies, Barry R., Cadogan, Elaine B.
發表在 Nat Commun (2019)

MCL1 and BCL-xL Levels in Solid Tumors Are Predictive of Dinaciclib-Induced Apoptosis

由 Booher, Robert N., Hatch, Harold, Dolinski, Brian M., Nguyen, Thi, Harmonay, Lauren, Al-Assaad, Ali-Samer, Ayers, Mark, Nebozhyn, Michael, Loboda, Andrey, Hirsch, Heather A., Zhang, Theresa, Shi, Bin, Merkel, Carrie E., Angagaw, Minilik H., Wang, Yaolin, Long, Brian J., Lennon, Xianlu Q., Miselis, Nathan, Pucci, Vincenzo, Monahan, James W., Lee, Junghoon, Kondic, Anna Georgieva, Im, Eun Kyung, Mauro, David, Blanchard, Rebecca, Gilliland, Gary, Fawell, Stephen E., Zawel, Leigh, Schuller, Alwin G., Strack, Peter
出版 2014

Design and optimisation of dendrimer-conjugated Bcl-2/x(L) inhibitor, AZD0466, with improved therapeutic index for cancer therapy

由 Patterson, Claire M., Balachander, Srividya B., Grant, Iain, Pop-Damkov, Petar, Kelly, Brian, McCoull, William, Parker, Jeremy, Giannis, Michael, Hill, Kathryn J., Gibbons, Francis D., Hennessy, Edward J., Kemmitt, Paul, Harmer, Alexander R., Gales, Sonya, Purbrick, Stuart, Redmond, Sean, Skinner, Matthew, Graham, Lorraine, Secrist, J. Paul, Schuller, Alwin G., Wen, Shenghua, Adam, Ammar, Reimer, Corinne, Cidado, Justin, Wild, Martin, Gangl, Eric, Fawell, Stephen E., Saeh, Jamal, Davies, Barry R., Owen, David J., Ashford, Marianne B.
發表在 Commun Biol (2021)

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

由 Tron, Adriana E., Belmonte, Matthew A., Adam, Ammar, Aquila, Brian M., Boise, Lawrence H., Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J., Gangl, Eric, Gibbons, Francis D., Gregory, Gareth P., Hargreaves, David, Hendricks, J. Adam, Johannes, Jeffrey W., Johnstone, Ricky W., Kazmirski, Steven L., Kettle, Jason G., Lamb, Michelle L., Matulis, Shannon M., Nooka, Ajay K., Packer, Martin J., Peng, Bo, Rawlins, Philip B., Robbins, Daniel W., Schuller, Alwin G., Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J. Paul, Clark, Edwin A., Wilson, David M., Fawell, Stephen E., Hird, Alexander W.
發表在 Nat Commun (2018)