Inhibition of STAT3 with the generation 2.5 antisense oligonucleotide, AZD9150, decreases neuroblastoma tumorigenicity and increases chemosensitivity

Por Odate, Seiichi, Veschi, Veronica, Yan, Shuang, Lam, Norris, Woessner, Richard, Thiele, Carol J.
Publicado no Clin Cancer Res (2016)

KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells

Por Kim, Ki Hyung, Xie, Yanhua, Tytler, Ewan M, Woessner, Richard, Mor, Gil, Alvero, Ayesha B
Publicado em 2009

Inhibition of KSP by ARRY-520 Induces Cell Cycle Block and Cell Death via the Mitochondrial Pathway in AML Cells

Por Carter, Bing Z., Mak, Duncan H., Woessner, Richard, Gross, Stefan, Schober, Wendy D., Estrov, Zeev, Kantarjian, Hagop, Andreeff, Michael
Publicado em 2009

Cytokine receptor signaling is required for the survival of ALK− anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations

Por Chen, Jing, Zhang, Yong, Petrus, Michael N., Xiao, Wenming, Nicolae, Alina, Raffeld, Mark, Pittaluga, Stefania, Bamford, Richard N., Nakagawa, Masao, Ouyang, Sunny Tianyi, Epstein, Alan L., Kadin, Marshall E., Del Mistro, Annarose, Woessner, Richard, Jaffe, Elaine S., Waldmann, Thomas A.
Publicado no Proc Natl Acad Sci U S A (2017)

Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma

Por Kuhn, Deborah J., Berkova, Zuzana, Jones, Richard J., Woessner, Richard, Bjorklund, Chad C., Ma, Wencai, Davis, R. Eric, Lin, Pei, Wang, Hua, Madden, Timothy L., Wei, Caimiao, Baladandayuthapani, Veerabhadran, Wang, Michael, Thomas, Sheeba K., Shah, Jatin J., Weber, Donna M., Orlowski, Robert Z.
Publicado em 2012

Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability

Por Hicken, Erik J., Marmsater, Fred P., Munson, Mark C., Schlachter, Stephen T., Robinson, John E., Allen, Shelley, Burgess, Laurence E., DeLisle, Robert Kirk, Rizzi, James P., Topalov, George T., Zhao, Qian, Hicks, Julie M., Kallan, Nicholas C., Tarlton, Eugene, Allen, Andrew, Callejo, Michele, Cox, April, Rana, Sumeet, Klopfenstein, Nathalie, Woessner, Richard, Lyssikatos, Joseph P.
Publicado em 2013

AZD9150, a Next-Generation Antisense Oligonucleotide Inhibitor of STAT3 with Early Evidence of Clinical Activity in Lymphoma and Lung Cancer

Por Hong, David, Kurzrock, Razelle, Kim, Youngsoo, Woessner, Richard, Younes, Anas, Nemunaitis, John, Fowler, Nathan, Zhou, Tianyuan, Schmidt, Joanna, Jo, Minji, Lee, Samantha J., Yamashita, Mason, Hughes, Steven G., Fayad, Luis, Piha-Paul, Sarina, Nadella, Murali VP, Mohseni, Morvarid, Lawson, Deborah, Reimer, Corinne, Blakey, David C., Xiao, Xiaokun, Hsu, Jeff, Revenko, Alexey, Monia, Brett P., MacLeod, A. Robert
Publicado no Sci Transl Med (2015)

Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors

Por Wenglowsky, Steve, Ren, Li, Ahrendt, Kateri A., Laird, Ellen R., Aliagas, Ignacio, Alicke, Bruno, Buckmelter, Alex J., Choo, Edna F., Dinkel, Victoria, Feng, Bainian, Gloor, Susan L., Gould, Stephen E., Gross, Stefan, Gunzner-Toste, Janet, Hansen, Joshua D., Hatzivassiliou, Georgia, Liu, Bonnie, Malesky, Kim, Mathieu, Simon, Newhouse, Brad, Raddatz, Nicholas J., Ran, Yingqing, Rana, Sumeet, Randolph, Nikole, Risom, Tyler, Rudolph, Joachim, Savage, Scott, Selby, LeAnn T., Shrag, Michael, Song, Kyung, Sturgis, Hillary L., Voegtli, Walter C., Wen, Zhaoyang, Willis, Brandon S., Woessner, Richard D., Wu, Wen-I, Young, Wendy B., Grina, Jonas
Publicado em 2011