Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability

[Image: see text] The in silico construction of a PDGFRβ kinase homology model and ensuing medicinal chemistry guided by molecular modeling, led to the identification of potent, small molecule inhibitors of PDGFR. Subsequent exploration of structure–activity relationships (SAR) led to the incorporat...

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Hauptverfasser: Hicken, Erik J., Marmsater, Fred P., Munson, Mark C., Schlachter, Stephen T., Robinson, John E., Allen, Shelley, Burgess, Laurence E., DeLisle, Robert Kirk, Rizzi, James P., Topalov, George T., Zhao, Qian, Hicks, Julie M., Kallan, Nicholas C., Tarlton, Eugene, Allen, Andrew, Callejo, Michele, Cox, April, Rana, Sumeet, Klopfenstein, Nathalie, Woessner, Richard, Lyssikatos, Joseph P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027622/
https://ncbi.nlm.nih.gov/pubmed/24900776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4003953
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