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Inhibition of STAT3 with the generation 2.5 antisense oligonucleotide, AZD9150, decreases neuroblastoma tumorigenicity and increases chemosensitivity
PURPOSE: Neuroblastoma (NB) is a pediatric tumor of peripheral sympathoadrenal neuroblasts. The long-term event-free survival of children with high-risk NB is still poor despite the improvements with current multimodality treatment protocols. Activated JAK/STAT3 pathway plays an important role in ma...
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| Publié dans: | Clin Cancer Res |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5381521/ https://ncbi.nlm.nih.gov/pubmed/27797972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1317 |
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