Novel Agents for Multiple Myeloma to Overcome Resistance in Phase III Clinical Trials

Por Orlowski, Robert Z.
Publicado em 2013

Why Proteasome Inhibitors Cannot ERADicate Multiple Myeloma

Por Orlowski, Robert Z.
Publicado em 2013

The future of treatment for patients with relapsed/refractory multiple myeloma: The Future of Proteasome Inhibitors in Relapsed/Refractory Multiple Myeloma

Por Orlowski, Robert Z.
Publicado em 2011

The role of the ubiquitination-proteasome pathway in breast cancer: Applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancer

Por Orlowski, Robert Z, Dees, E Claire
Publicado em 2003

The Immunoproteasome as a Target in Hematologic Malignancies

Por Kuhn, Deborah J., Orlowski, Robert Z.
Publicado em 2012

Proteasome Inhibitors in the Treatment of Multiple Myeloma

Por Shah, Jatin J., Orlowski, Robert Z.
Publicado no Leukemia (2009)

Bortezomib and EGCG: no green tea for you?

Por Shah, Jatin J., Kuhn, Deborah J., Orlowski, Robert Z.
Publicado em 2009

Role of combination bortezomib and pegylated liposomal doxorubicin in the management of relapsed and/or refractory multiple myeloma

Por Shah, Jatin J, Orlowski, Robert Z, Thomas, Sheeba K
Publicado em 2009

Novel Approaches to Treatment of “Double-Refractory” Multiple Myeloma

Por Lee, Hans C., Shah, Jatin J., Orlowski, Robert Z.
Publicado em 2013

Biological Effects of the Pim Kinase Inhibitor, SGI-1776, in Multiple Myeloma

Por Cervantes-Gomez, Fabiola, Chen, Lisa S., Orlowski, Robert Z., Gandhi, Varsha
Publicado em 2013

Bayesian Joint Selection of Genes and Pathways: Applications in Multiple Myeloma Genomics

Por Zhang, Lin, Morris, Jeffrey S, Zhang, Jiexin, Orlowski, Robert Z, Baladandayuthapani, Veerabhadran
Publicado no Cancer Inform (2014)

Osteoblastic niche supports the growth of quiescent multiple myeloma cells

Por Chen, Zheng, Orlowski, Robert Z., Wang, Michael, Kwak, Larry, McCarty, Nami
Publicado em 2014

EFFICACY OF PANOBINOSTAT AND MARIZOMIB IN ACUTE MYELOID LEUKEMIA AND BORTEZOMIB-RESISTANT MODELS

Por Corrales-Medina, Fernando F., Manton, Christa A., Orlowski, Robert Z., Chandra, Joya
Publicado no Leuk Res (2015)

Drug Resistance to Inhibitors of the Human Double Minute-2 E3 Ligase is Mediated by Point Mutations of p53, but can be Overcome with the p53 Targeting Agent RITA

Por Jones, Richard J., Bjorklund, Chad C., Baladandayuthapani, Veerabhadran, Kuhn, Deborah J., Orlowski, Robert Z.
Publicado em 2012

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhib...

Por Kuhn, Deborah J., Hunsucker, Sally A., Chen, Qing, Voorhees, Peter M., Orlowski, Marian, Orlowski, Robert Z.
Publicado em 2009

Targeting the Pro-Survival Protein MET with Tivantinib (ARQ 197) Inhibits Growth of Multiple Myeloma Cells()()

Por Zaman, Shadia, Shentu, Shujun, Yang, Jing, He, Jin, Orlowski, Robert Z., Stellrecht, Christine M., Gandhi, Varsha
Publicado no Neoplasia (2015)

Expression of histone deacetylases in lymphoma: Implication for the development of selective inhibitors

Por Gloghini, Annunziata, Buglio, Daniela, Khaskhely, Noor M., Georgakis, Georgios, Orlowski, Robert Z., Neelapu, Sattva S., Carbone, Antonino, Younes, Anas
Publicado em 2009

Rapid early monoclonal protein reduction after therapy with bortezomib or bortezomib and pegylated liposomal doxorubicin in relapsed/refractory myeloma is associated with a longer...

Por Shah, Jatin, Bladé, Joan, Sonneveld, Pieter, Harousseau, Jean-Luc, Lantz, Keith, Londhe, Anil, Lowery, Colin, Orlowski, Robert Z.
Publicado em 2011

Dynamic balance of multiple myeloma clonogenic side population cell percentages controlled by environmental conditions

Por Wen, Jianguo, Tao, Wenjing, Kuiatse, Isere, Lin, Pei, Feng, Yongdong, Jones, Richard J., Orlowski, Robert Z., Zu, Youli
Publicado no Int J Cancer (2014)

Inhibition of the p53 E3 Ligase HDM-2 Induces Apoptosis and DNA Damage-Independent p53 Phosphorylation in Mantle Cell Lymphoma

Por Jones, Richard J., Chen, Qing, Voorhees, Peter M., Young, Ken H., Bruey-Sedano, Nathalie, Yang, Dajun, Orlowski, Robert Z.
Publicado em 2008