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Biological Effects of the Pim Kinase Inhibitor, SGI-1776, in Multiple Myeloma
Pim kinases are constitutively active serine/threonine/tyrosine kinases that are overexpressed in hematological malignancies such as multiple myeloma. Pim kinase substrates are involved in transcription, protein translation, cell proliferation, and apoptosis. SGI-1776 is a potent Pim kinase inhibito...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3951475/ https://ncbi.nlm.nih.gov/pubmed/23988451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clml.2013.05.019 |
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