Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

Pim kinases are Ser/Thr kinases with multiple substrates that affect survival pathways. These proteins are overexpressed in acute myeloid leukemia (AML) blasts and we hypothesized that Pim kinase inhibition would affect AML cell survival. Imidazo[1,2-b]pyridazine compound, SGI-1776 inhibits Pim-1, P...

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Detaylı Bibliyografya
Asıl Yazarlar: Chen, Lisa S., Redkar, Sanjeev, Taverna, Pietro, Cortes, Jorge E., Gandhi, Varsha
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2011
Konular:
Myeloid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142906/
https://ncbi.nlm.nih.gov/pubmed/21628411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-323022
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