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Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells
Pim kinases are involved in B-cell development and are overexpressed in B-cell chronic lymphocytic leukemia (CLL). We hypothesized that Pim kinase inhibition would affect B-cell survival. Identified from a screen of imidazo[1,2-b]pyridazine compounds, SGI-1776 inhibits Pim-1, Pim-2, and Pim-3. Treat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2774551/ https://ncbi.nlm.nih.gov/pubmed/19734450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-212852 |
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