Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

Pim kinases are involved in B-cell development and are overexpressed in B-cell chronic lymphocytic leukemia (CLL). We hypothesized that Pim kinase inhibition would affect B-cell survival. Identified from a screen of imidazo[1,2-b]pyridazine compounds, SGI-1776 inhibits Pim-1, Pim-2, and Pim-3. Treat...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Chen, Lisa S., Redkar, Sanjeev, Bearss, David, Wierda, William G., Gandhi, Varsha
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2009
Teme:
Lymphoid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774551/
https://ncbi.nlm.nih.gov/pubmed/19734450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-212852
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki