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Protein Profiling Identifies mTOR Pathway Modulation and Cytostatic Effects of Pim Kinase Inhibitor, AZD1208, in Acute Myeloid Leukemia

Pim kinases phosphorylate and regulate a number of key AML cell survival proteins, and Pim inhibitors have recently entered clinical trial for hematological malignancies. AZD1208 is a small molecule pan-Pim kinase inhibitor and AZD1208 treatment resulted in growth inhibition and cell size reduction...

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書目詳細資料
發表在:Leuk Lymphoma
Main Authors: Chen, Lisa S., Yang, Ji-Yeon, Liang, Han, Cortes, Jorge E., Gandhi, Varsha
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650058/
https://ncbi.nlm.nih.gov/pubmed/27054578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2016.1166489
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