The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression

Mammalian target of rapamycin (mTOR) signaling is a critical pathway in the biology of acute myeloid leukemia (AML). Proviral integration site for moloney murine leukemia virus (PIM) serine/threonine kinase signaling takes part in various pathways exerting tumorigenic properties. We hypothesized tha...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Harada, Masako, Benito, Juliana, Yamamoto, Shinichi, Kaur, Surinder, Arslan, Dirim, Ramirez, Santiago, Jacamo, Rodrigo, Platanias, Leonidas, Matsushita, Hiromichi, Fujimura, Tsutomu, Kazuno, Saiko, Kojima, Kensuke, Tabe, Yoko, Konopleva, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741975/
https://ncbi.nlm.nih.gov/pubmed/26473447
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