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ATP Analog Enhances the Actions of a Heat Shock Protein 90 Inhibitor in Multiple Myeloma Cells

Heat shock protein (HSP) 90 regulates client oncoprotein maturation. The chaperone function of HSP90 is blocked by 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), although it results in transcription and translation of antiapoptotic HSP proteins. Using three myeloma cell lines, we tested whether...

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Detalhes bibliográficos
Main Authors: Cervantes-Gomez, Fabiola, Nimmanapalli, Ramadevi, Gandhi, Varsha
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199983/
https://ncbi.nlm.nih.gov/pubmed/21821695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.184903
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