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Transcription Inhibition of Heat Shock Proteins: A Strategy for Combination of 17-allylamino-17-demethoxygeldanamycin and Actinomycin D

The heat shock protein (HSP) 90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) is currently in clinical trials because of its unique mechanism of action and antitumor activity. However, 17-AAG triggers the transcription and elevation of antiapoptotic HSP90, HSP70, and HSP27, which lead to...

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Detalhes bibliográficos
Main Authors: Cervantes-Gomez, Fabiola, Nimmanapalli, Ramadevi, Gandhi, Varsha
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778753/
https://ncbi.nlm.nih.gov/pubmed/19383903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4406
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