Targeting the Pro-Survival Protein MET with Tivantinib (ARQ 197) Inhibits Growth of Multiple Myeloma Cells()()

The hepatocyte growth factor (HGF)/MNNG HOS transforming gene (MET) pathway regulates cell growth, survival, and migration. MET is mutated or amplified in several malignancies. In myeloma, MET is not mutated, but patients have high plasma concentrations of HGF, high levels of MET expression, and gen...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Zaman, Shadia, Shentu, Shujun, Yang, Jing, He, Jin, Orlowski, Robert Z., Stellrecht, Christine M., Gandhi, Varsha
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372650/
https://ncbi.nlm.nih.gov/pubmed/25810013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2015.01.006
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