Cytotoxic activity of Tivantinib (ARQ 197) is not due solely to MET inhibition

The receptor tyrosine kinase c-MET is the high-affinity receptor for the hepatocyte growth factor (HGF). The HGF/c-MET axis is often dysregulated in tumors. c-MET activation can be caused by MET gene amplification, activating mutations, and auto- or paracrine mechanisms. Thus, c-MET inhibitors are u...

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Bibliographic Details
Main Authors: Katayama, Ryohei, Aoyama, Aki, Yamori, Takao, Qi, Jie, Oh-hara, Tomoko, Song, Youngchul, Engelman, Jeffrey A., Fujita, Naoya
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759033/
https://ncbi.nlm.nih.gov/pubmed/23598276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3256
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