Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines

BACKGROUND: MET is a receptor tyrosine kinase that is activated by the ligand HGF and this pathway promotes cell survival, migration, and motility. In accordance with its oncogenic role, MET is constitutively active, mutated, or over-expressed in many cancers. Corollary to its impact, inhibition of...

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Bibliografski detalji
Glavni autori: Phillip, Cornel Joseph, Zaman, Shadia, Shentu, Shujun, Balakrishnan, Kumudha, Zhang, Jiexin, Baladandayuthapani, Veera, Taverna, Pietro, Redkar, Sanjeev, Wang, Michael, Stellrecht, Christine Marie, Gandhi, Varsha
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878866/
https://ncbi.nlm.nih.gov/pubmed/24326130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-6-92
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