Inhibition of KSP by ARRY-520 Induces Cell Cycle Block and Cell Death via the Mitochondrial Pathway in AML Cells

Eitemau Tebyg

• KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells
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  Cyhoeddwyd: (2009)
• A Phase 1 Dose-Escalation Study of ARRY-520, a KSP Inhibitor, in Patients with Advanced Myeloid Leukemias
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  Cyhoeddwyd: (2011)
• Triptolide induces cell death independent of cellular responses to imatinib in blast crisis CML cells including quiescent CD34(+) primitive progenitor cells
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  Cyhoeddwyd: (2009)
• Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells
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• Activation of Apoptosis Signaling Eliminates CD34(+) Progenitor Cells in Blast Crisis CML Independent of Response to Tyrosine Kinase Inhibitors
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  Cyhoeddwyd: (2011)