Inhibition of KSP by ARRY-520 Induces Cell Cycle Block and Cell Death via the Mitochondrial Pathway in AML Cells

Kinesin spindle protein (KSP), a microtubule-associated motor protein essential for cell cycle progression, is overexpressed in many cancers and a potential anti-tumor target. We found that inhibition of KSP by a selective inhibitor, ARRY-520, blocked cell cycle progression, leading to apoptosis in...

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Detalhes bibliográficos
Main Authors: Carter, Bing Z., Mak, Duncan H., Woessner, Richard, Gross, Stefan, Schober, Wendy D., Estrov, Zeev, Kantarjian, Hagop, Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593228/
https://ncbi.nlm.nih.gov/pubmed/19458629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2009.101
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