A Phase 1 Dose-Escalation Study of ARRY-520, a KSP Inhibitor, in Patients with Advanced Myeloid Leukemias

BACKGROUND: ARRY-520 selectively inhibits the mitotic kinesin spindle protein (KSP), which leads to abnormal monopolar spindle formation and apoptosis. METHODS: A Phase 1 trial was conducted to establish the safety and the maximum tolerated dose (MTD) of ARRY-520 given as a 1-hour infusion in either...

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Vydáno v:Cancer
Hlavní autoři: Khoury, Hanna Jean, Garcia-Manero, Guillermo, Borthakur, Gautam, Kadia, Tapan, Foudray, Maria Cielo, Arellano, Martha, Langston, Amelia, Bethelmie-Bryan, Beverly, Rush, Selena, Litwiler, Kevin, Karan, Sharon, Simmons, Heidi, Marcus, Adam I., Ptaszynski, Mieke, Kantarjian, Hagop
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984525/
https://ncbi.nlm.nih.gov/pubmed/22139909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.26664
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