Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells

Triptolide, a diterpenoid isolated from the Chinese herb Tripterygium wilfordii Hook.f, has shown antitumor activities in a broad range of solid tumors. Here, we examined its effects on leukemic cells and found that, at 100 nM or less, it potently induced apoptosis in various leukemic cell lines and...

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Bibliographic Details
Main Authors: Carter, Bing Z., Mak, Duncan H., Schober, Wendy D., McQueen, Teresa, Harris, David, Estrov, Zeev, Evans, Randall L., Andreeff, Michael
Format: Artigo
Language:Inglês
Published: The American Society of Hematology 2006
Subjects:
Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895484/
https://ncbi.nlm.nih.gov/pubmed/16556893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-09-3898
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