Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

Acute myeloid leukemia (AML) cells are relatively resistant to tumor necrosis factor α–related apoptosis-inducing ligand (TRAIL). We previously reported that triptolide, a potent anticancer agent from a Chinese herb, decreases XIAP in leukemic cells. We evaluated the combination of triptolide and TR...

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Détails bibliographiques
Auteurs principaux: Carter, Bing Z., Mak, Duncan H., Schober, Wendy D., Dietrich, Martin F., Pinilla, Clemencia, Vassilev, Lyubomir T., Reed, John C., Andreeff, Michael
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2008
Sujets:
Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275030/
https://ncbi.nlm.nih.gov/pubmed/18187663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-091504
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